The drug is excreted largely inside the urine, mainly as inactive metabolites and compact quantities of cost-free and conjugated morphine. Negligible quantities of codeine and its metabolites are present in the feces.
Promethazine HCl and Codeine Phosphate Oral Solution needs to be employed with caution in patients with impairment of hepatic operate, and clients ought to be monitored carefully for respiratory melancholy, sedation, and hypotension.
sufferers that are allergic to promethazine, any with the elements in promethazine, or to other phenothiazines
Promethazine is perfectly absorbed with the gastrointestinal tract. Medical effects are evident inside of twenty minutes immediately after oral administration and usually last 4 to six hrs, While They might persist given that 12 hours.
Postmarketing instances of respiratory depression, together with fatalities have already been documented with utilization of promethazine in pediatric clients.
Focus–Adverse Reaction Interactions There's a marriage in between increasing codeine plasma concentration and raising frequency of dose- connected opioid adverse reactions including nausea, vomiting, CNS outcomes, and respiratory despair.
Promethazine HCl could possibly be used on your own or being an adjunct to narcotic analgesics during labor (see DOSAGE AND ADMINISTRATION). Constrained data recommend that utilization of Promethazine during labor and shipping and delivery does not have an appreciable impact on the period of labor or supply and doesn't raise the hazard of require for intervention while in the new child.
Particular scientific tests to check the motion of the drug on parturition, lactation, and improvement in the animal neonate were not accomplished, but a standard preliminary examine in rats indicated no effect on these parameters.
Right after initiation of cure promethazine quagen in children or adults, dosage must be modified to your least amount suitable To ease signs and symptoms. The administration of Promethazine HCl in 25-mg doses will Manage small transfusion reactions of an allergic nature.
Promethazine HCl occurs like a white to faint yellow, almost odorless, crystalline powder which little by little oxidizes and turns blue on extended exposure to air. It truly is freely soluble in h2o and soluble in Alcoholic beverages.
Concomitant administration of Promethazine items with other respiratory depressants has an association with respiratory melancholy, and often Demise, in pediatric sufferers.
The mixture of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric sufferers below 6 many years of age, simply because The mix may possibly result in lethal respiratory depression In this particular age population (see WARNINGS Box Warning and Use in Pediatric Patients).
Sedation This item relieves apprehension and induces a quiet slumber from which the client might be very easily aroused.
The treatment of choice for ensuing hypotension is administration of intravenous fluids, accompanied by repositioning if indicated. In the event that vasopressors are viewed as to the administration of extreme hypotension which will not reply to intravenous fluids and repositioning, the administration of norepinephrine or phenylephrine needs to be thought of.